Patrick Sexton is a leading international researcher in the field of G protein-coupled receptors (GPCRs), and in particular with respect to allosteric modulation of receptors, ligand-directed signal bias and in the structure/function of Class B GPCRs and accessory proteins. His research crosses industry and academic boundaries through elucidation of fundamental biology and the intersection of this with drug-receptor interactions. He has authored over 200 publications, with major contributions to understanding of the distribution of receptors, the structural interface between peptide ligands and receptors, modulation of receptors by accessory proteins, detection and quantification of small molecule allosteric drug effects and ligand-biased signalling. He is currently a NHMRC Principal Research fellow and 2014 Thomson Reuters highly cited researcher.
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